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Grant recipient

Thomas Jensen

Exploring Mechanistic Determinants of Striated Muscle Insulin-sensitivity across the Health-Disease Spectrum (SIDETRAC
Grant amount: DKK 9.967.311

Among its many important effects, the hormone insulin binds to antennas on heart and skeletal muscle cells and transmits a signal inside to open doorways called GLUT4 in the cells to allow glucose to enter. The ability of insulin to stimulate glucose entrance fails in a process called insulin-resistance. Insulin resistance contributes to the early development of type 2 diabetes and cardiovascular disease and prevention and treatment strategies are therefore desirable. Insulin resistance is commonly explained by the insulin antenna failing to transmit its signal, but we suspect – based on preliminary work – that the inside of cells becomes progressively messier in insulin resistance and that GLUT4 is instead moved out of reach of the insulin signal. To test this idea in-depth in humans, we will develop new advanced microscopy tools to analyse human skeletal muscle biopsies and human 3D stem cell models of heart and skeletal muscle.

Thomas Jensen
Thomas Jensen
Associate Professor, KĂžbenhavns Universitet, Department of Nutrition, Exercise and Sports