Stefan Stender says: “This project aims to identify genetic factors that influence progression of five common diseases: type 2 diabetes, ischemic heart disease, chronic kidney disease, fatty liver disease, and chronic obstructive pulmonary disease. We hypothesize that there are distinct ‘onset-promoting’ and ‘progression-promoting’ genetic factors for any given disease. To test this, we will scan the genomes of 600,000 persons from the British and Danish population for genetic variants that affect disease progression. The genetic variants identified in the project have the potential to yield new insights into the factors that drive human disease. Such insights may ultimately inspire the development of new drugs targeting the causal pathways, aiming to forestall or even reverse disease progression.”
Stefan Stender has been a staff specialist at the Department of Clinical Biochemistry, Rigshospitalet, since 2021.