The World Health Organization reports that 6% of all deaths are due to alcohol abuse, primarily from accidents, violence, and alcoholic liver disease (ALD). ALD is the commonest form of liver disease in Western countries including Denmark and England, yet research into ALD is neglected. ALD causes 50% of the liver disease burden but receives only 5% of the research attention. Most deaths among patients with ALD are from complications of cirrhosis of the liver or from primary cancer of the liver (hepatocellular carcinoma). This project will give us new insight into the factors that determine the prognosis for patients who have ALD or are at high risk of developing ALD due to hazardous alcohol consumption. We aim to reduce the burden of ALD on patients and healthcare systems. The knowledge gained from the project should be used to design screening programs for individuals who are at high risk of ALD, and to optimize care for patients diagnosed with ALD.