Grant recipientOleksiy Kovtun says: “Living cells constantly move materials between their compartments to maintain their health and perform assigned roles. This transport relies on nanomachines that recognise molecules and redirect them to correct transport streams. My research will look into the organisation of such nanomachines that function in logistics hubs of intracellular trafficking called endosomes. Using novel microscopy methods capable of capturing entire nanomachines rather than their individual parts both in the isolated state or directly within the cell, I will discover how they act in connecting molecular selection to a specific transport itinerary, and how they cooperate between each other to create processing pipelines in endosomes. This knowledge will shed light on how endosomal transport that is often impaired in pathologies such as Alzheimer's and Parkinson's disease and chronic inflammation could be targeted with drugs to relief and cure these diseases in the future.”
Structural dissection of key molecular machines mediating membrane trafficking in endosomes
Grant amount: DKK 9,988,579
Oleksiy Kovtun will relocate from his postdoctoral position at the MRC Laboratory of Molecular Biology, Cambridge, United Kingdom to set up his independent research group at Aarhus University, where he will have access to state-of-the-art equipment, infrastructure and knowhow.