Grant recipient

Nikolaj Fibiger Rittig

Stimulating the human gut-brain-appetite axis
Grant amount: DKK 9,999,468

Nikolaj Fibiger Rittig says: “The gut plays an important role for metabolic health and appetite regulation. We will explore how different compounds affect the gut and regulates metabolism and appetite (the gut-brain-appetite axis). Lactate is particularly high in fermented food products and we have recently shown that lactate stimulates gastrointestinal hormone secretion, and slows gastric emptying. Lactate is also produced and converted into the metabolite N-lactoyl-phenylalanine (lac-phe) and studies in mice suggests that lac-phe may induce satiety and weight loss. Butyrate is a small fatty acid mainly produced by bacteria in the colon where it may elevate energy expenditure, improve immune functions, and regulate appetite. The overall aim with this project is to perform a series of human clinical studies that investigate how different compounds (lactate, lac-phe, and butyrate) activate and affect the gut-brain-appetite system”.

Nikolaj Fibiger Rittig has for several years been associated with the Steno Diabetes Center Aarhus, Aarhus University Hospital. He is currently doing his specialist training at Klinik for Hormon og knoglesygdomme at Aarhus University Hospital. He says further: “The Clinical Emerging Investigator fellowship will allow me to build my own research group with focus on gut-brain-appetite regulation, perform research at a high international level and continue my work as combined clinician and researcher”.

Nikolaj Fibiger Rittig
Nikolaj Fibiger Rittig
Resident, Hormon og knoglesygdomme - Steno Diabetes Center Aarhus, Aarhus University Hospital