Regulation of DNA–Protein Crosslink Repair in Health and Disease
Niels Mailand says: “Many chemotherapeutic agents give rise to the formation of DNA–protein crosslinks, a highly toxic form of damage to the genetic material within our cells. However, little is known about how human cells respond to and overcome such lesions. Using cutting-edge methods within cell and protein biology, this project will explore how the cellular response to DNA–protein crosslinks is organized and regulated at the molecular level and how targeted inhibition of such processes may be exploited in improving treatment strategies for cancer.”
Professor and Group Leader, Novo Nordisk Foundation Center for Protein Research
University of Copenhagen
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