Grant recipient

Myriam Aouadi

Role of RNA Regulation in Macrophages in the Development and Correction of Metabolic Diseases
Grant amount: DKK 9.704.634
Myriam Aouadi says: “Given its major role in the metabolism of nutrients, the liver plays a central role in the control of metabolic homeostasis. We have recently shown that macrophages could directly regulate glucose metabolism and fat accumulation in obese livers via a factor denoted insulin-like growth factor–binding protein 7 (IGFBP7). In humans, IGFBP7 underwent RNA modification, called RNA editing, a molecular process through which some cells can make discrete changes to specific nucleotide sequences within an RNA molecule after it has been generated. RNA editing of IGFBP7 led to modification of the protein sequence and its capacity to regulate insulin signalling. Here we propose to study the functional role and regulation of RNA editing in macrophages in insulin resistance. Because of the reversible nature of RNA editing (because cells are constantly making new copies of RNA), it holds promise for future therapeutic strategies in obesity and type 2 diabetes.”
Myriam Aouadi
Myriam Aouadi, Senior Researcher
Department of Medicine Huddinge, Karolinska Institutet, Sweden