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Grant recipient

Lene Niemann Nejsum

The renal urinary concentration mechanism: towards a detailed model of AQP2 shuttling
Grant amount: DKK 10,000,000
Lene Niemann Nejsum says: “Multiple diseases are associated with dysregulation of body water balance; either water loss or water retention. In the kidneys, a water channel protein, aquaporin-2 (AQP2), is pivotal in regulation of urine concentration and hence, in regulation of body water balance. AQP2 is dysregulated in multiple water balance disorders. My team will use newly developed bioimaging methods which enable visualization of AQP2 in renal cells. We will use these methods to generate a new level of understanding regarding the mechanisms which regulate AQP2. This understanding will advance the ability to develop treatments based on targeting AQP2 dysregulation to restore body water balance.”
Lene Niemann Nejsum
Lene Niemann Nejsum
Associate Professor, Department of Clinical Medicine, Aarhus University

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