Grant recipient

Henrik Schytz

Unraveling Cerebrospinal Fluid Dynamics and Disease Mechanisms In Spontaneous Intracranial Hypotension
Grant amount: DKK 9,917,724

Henrik Schytz says: “Spontaneous intracranial hypotension (SIH) is a serious and underdiagnosed brain disease characterized by low cerebrospinal fluid (CSF) pressure caused by a leak in the membranes surrounding the brain and spinal cord. In SIH, brain function is severely affected, leading to cognitive dysfunction and severe headache when standing up. The current study will investigate 500 patients suspected of SIH with state-of-the-art diagnostic tests and imaging methods to diagnose and predict the outcome of SIH. The study will also investigate SIH patients before and after treatment in comparison to healthy controls using advanced 7 Tesla magnetic resonance imaging (7T MRI). The 7T MRI studies will demonstrate how SIH affects brain regions that control CSF flow and clearance of brain waste products. The study will lead to new knowledge and methods on how brain function is affected by changes in intracranial pressure, which can be applied in many other neurological conditions.”

Henrik Schytz is Consultant in Neurology, Danish Headache Center, Rigshospitalet-Glostrup, and leader of the Headache Diagnostic Laboratory, Danish Headache Center. Henrik Schytz has been Associate Professor at Department of Clinical Medicine at University of Copenhagen since 2016.

Henrik Schytz
Department of Neurology, Danish Headache Center, Rigshospitalet-Glostrup