Grant recipient

Guillermo Montoya

GENED_2.0: From Molecular Mechanisms to the Next Generation of Genome Editing Tools
Grant amount: DKK 10,000,000

Guillermo Montoya says: “Genome editing is a technology that allows modification of the instructions contained in a genome and perhaps to “write” a new set of instructions to generate new genomes using the genetic code. This technology can be applied in therapeutics, especially in diseases where mutations produce illnesses and where a cell type is amenable for modification, such as for example bone marrow cells. Therefore, genome editing can be applied, to correct mutations causing rare diseases and certain types of cancer. To improve these applications, we need to get full mechanistic understanding of the “tools” that we use to initiate the modification. My proposal focuses in deciphering the working mechanisms of different CRISPR-Cas systems to provide better molecular scissors for various applications.”

Guillermo Montoya
Professor, Novo Nordisk Foundation Center for Protein Research
University of Copenhagen