Polycystic ovary syndrome (PCOS) is the leading cause of female infertility and linked to type-2 diabetes and cancer. Progress in managing the disorder is hindered by lack of insight into the underlying mechanisms. We know that male hormones plays a key role and that PCOS runs in families. Recently we made the discovery that PCOS-like symptoms, induced by exposing pregnant mice to male hormone, are passed down from mothers to great-granddaughters. Moreover, we have indications that sons can transmit the disease as well.
I will take a multidisciplinary approach to get better insights into how PCOS is passed on in families. We will use human and mouse studies as well as state-of-the-art molecular techniques to dissect the key mechanisms that influence how the syndrome is passed on across generations both by women and men. My vision is to open new horizons for prevention strategies rather than managing symptoms, thereby markedly reducing the burden of the disease in both women and men.