Christian Schnepel

Amides form an essential chemical connection formed by condensation of a carboxylic acid and an amine. These acylation reactions assemble molecular scaffolds to form complex molecules, a vital step for production of numerous chemicals. Traditional chemical approaches used to create this important bond are often inefficient and contribute significantly to the environmental footprint of chemical industries. Thus, development of sustainable syntheses for amides, peptides, and beyond is paramount to meet the growing demand for pharmaceuticals against diabetes, cancer, and cardiovascular diseases. Central to our project are thioesters of coenzyme A, a vitamin B₅ derivative that functions as nature’s mediator for activating and carrying carboxylic acids in metabolism. Inspired by this nature-based approach, Bio-ATEAM will unlock green acylation techniques through developing new-to-nature biocatalysts and multi-enzyme cascades, enabling synthesis of amides, peptides, and related acyl compounds. Ultimately, our enzyme-driven strategy will be instrumental to sustainably manufacture next-generation fine chemicals and drugs.