Anja Groth

Anja Groth says: “Epigenetic cell memory guides embryonic development and counteract disease in adults. All cells in our body contain the same DNA sequence, yet cells have distinct properties matching their functions as for example nerve or muscle cells. During development, this complexity arises gradually through activation and maintenance of different gene regulatory programs. The genome is organized into a structure called chromatin, which sets the stage for gene regulation and allows the proper programs to be executed while setting a barrier for expression of unwarranted genes. Chromatin structure can be propagated to daughter cells, providing epigenetic cellular memory that maintains cell identity and fate. Histone proteins, the core component of chromatin, can be chemically modified and these modifications are thought carry epigenetic information. This research project will dissect molecularly how histones are inherited to daughter cells and reveal their function in epigenetic cell memory.”