Unravelling novel molecular mechanisms of cardiac arrhythmia from onco-cardiology
Grant amount: DKK 9,894,737
Alicia Lundby says: “Cardiac arrhythmias are a leading cause of death in the Western world, partly because the molecular causes are not well established. New insights into causal mechanisms are becoming apparent from cancer patients treated with tyrosine kinase inhibitors who develop drug-dependent cardiac arrhythmias. It is, at present, unclear why the inhibitors cause arrhythmia. Based on such observations from onco-cardiology I propose tyrosine kinase signaling as a novel causal mechanism of arrhythmias. In this project I propose to identify the proteins and signaling pathways that cause the problematic effects of tyrosine kinase inhibitors in the heart. To do so, I will perform quantitative analyses of phosphotyrosine dependent signaling in the heart and identify dysregulation caused by arrhythmogenic cancer drug stimulation. This will allow us to outline phosphotyrosine signaling in the healthy heart, and to understand how dysregulation hereof is linked to arrhythmia.”
Associate Professor, Department of Biomedical Sciences, University of Copenhagen
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