Animal egg and sperm cells are made by special germ cells to carry genetic information across generations, enabling reproduction. Yet, we don't fully understand how germ cells control the genome to enable reproduction. This project aims to fill these gaps by studying how copies (paralogs) of key gene regulators help germ cells develop.
All animal cells rely on core protein complexes for gene activation. These complexes were thought to work the same in all cells, but recent discoveries show germ cells use paralogs to change gene regulation. We believe these paralog proteins form unique pathways specific to germ cells.
To explore this, we will study paralog proteins in germ cells using a fly model system. This research is crucial for understanding human infertility and could lead to future treatments. We will connect years of genetic research to uncover the molecular pathways behind germ cell function, providing insights into developmental failures and potential interventions.