Grant recipient

Morten Frost Nielsen

GLucagon-like peptide One & BonE (GLOBE): Studies on the role of GLP1 as a nutrient sensing mechanism regulating bone metabolism
Grant amount: DKK 9,987,120

Morten Frost Nielsen says: “Bone is an active tissue that is remodelled by resorption and formation of bone throughout life. Imbalanced bone remodelling may impair bone and increase fracture risk, e.g. osteoporosis and type 2 diabetes (T2D). Glucagon like peptide-1 (GLP1), a gut-secreted hormone, promotes insulin secretion when food is consumed and improves bone formation in animal studies. The hypothesis of Morten Frost and his group is that GLP1 acts as a nutrient sensor that signals availability of nutrients for bone remodelling. This project aims to determine the effects of GLP1 on bone formation, mass and strength by investigating the effects of treatment with GLP1 and GLP1-like drugs, currently used to treat T2D, on bone cells and bone in healthy individuals and T2D patients with low bone mass. If GLP1 and GLP1-like drugs are beneficial to bone in humans, this investigation will help repurposing GLP1-like drugs as a novel treatment of patients with conditions associated with increased fracture risk including osteoporosis and T2D.”

Morten Frost Nielsen
Clinical Associate Professor, Department of Endocrinology
University of Southern Denmark