Grant recipient

Mattias Carlstrom

Effects of dietary nitrate supplementation in type 2 diabetes and associated liver steatosis
Grant amount: DKK 8,610,000

Metabolic disorders including type 2 diabetes (T2D) have reached epidemic levels in the industrialized world and is closely coupled with overweight and obesity. It is well known that a diet rich in vegetables has favorable cardiometabolic effects, however, the protective component(s) in such diet remain unclear.

Mattias Carlstrom says: “We have demonstrated that supplementation with inorganic nitrate, which is highly abundant in green leafy vegetables, has favorable effects on cardiovascular and metabolic functions”. The mechanisms are linked to increased nitric oxide production and reduction of oxidative stress. This translational project explores the therapeutic potential, and underlying mechanisms, of dietary nitrate treatment in T2D and associated adverse complications. Results from this proposal may lay a foundation for therapeutic use of nitrate alone or in combination with antidiabetic drugs in T2D and may also lead to novel and specific dietary approaches to prevent the disease.”

Mattias Carlstrom
Associate Professor, Department of Physiology and Pharmacology
Karolinska Institutet