Marie Sofie Møller

To tackle the climate and environmental impact of chemical industrial processes, enzymes have emerged as a promising solution capable of radically minimizing the use of harsh chemicals and lowering consumption. Unfortunately, the enzymes available today are rarely directly suitable for these processes. However, fast-growing advanced techniques, such as computational protein design, enable us to improve existing enzymes or even create new ones. What sets EDFuSE apart is its holistic approach considering the enzyme multi-domain structure. Our focus is on the mutual organization and interplay of different domains with polymeric substrates, for optimal performance under industrial conditions. We will delve into the intricate details of enzyme structure and function to convert particularly complex materials and develop a versatile toolbox dedicated to enzyme engineering. EDFuSE represents a significant step toward more sustainable and eco-friendly industrial processes.