Lene Niemann Nejsum says: “Multiple diseases are associated with dysregulation of body water balance; either water loss or water retention. In the kidneys, a water channel protein, aquaporin-2 (AQP2), is pivotal in regulation of urine concentration and hence, in regulation of body water balance. AQP2 is dysregulated in multiple water balance disorders. My team will use newly developed bioimaging methods which enable visualization of AQP2 in renal cells. We will use these methods to generate a new level of understanding regarding the mechanisms which regulate AQP2. This understanding will advance the ability to develop treatments based on targeting AQP2 dysregulation to restore body water balance.”