Kirsi Pietiläinen explains: “The current proposal is based on two key findings from our research, suggesting that 1) obesity impairs the function of mitochondria, the energy-producing cell organelles of fat tissue and 2) paradoxically, mitochondrial function further reduces during diet-induced weight loss. In this project, we will examine how to restore mitochondrial function, to improve long-term weight-loss results. We study bariatric surgery and gut hormone (semaglutide) therapies as potential boosters of fat tissue mitochondria in patients who have type 2 diabetes and obesity. Further, we analyse the links between improved mitochondria, weight loss and glucose homeostasis. To gain mechanistic insight, we will test the effects of novel compounds induced by bariatric surgery on mitochondrial function in fat cells. The long-term aim of our project is to facilitate the development of mitochondria-based therapies for type 2 diabetes and obesity and to provide scientific breakthroughs for sustainable weight loss.”