Muscle health is perhaps the most important factor for overall health and prevention of metabolic disorders, age-related conditions, and reducing mortality risk. Recent technological advances have identified thousands of molecular changes linked to exercise and muscle health, but their roles in improving metabolism and preventing disease – if any – remain unclear, which hinders progress in drug discovery.

This project uses innovative tools to study how exercise affects muscle health, combining modern imaging and genetics with advanced research models. We will explore key pathways that improve muscle function and metabolism, which will help us identify targets for new treatments. By testing drugs already approved for human use as well as natural compounds, we aim to find therapies that protect against muscle loss and metabolic disease. Our goal is to develop strategies for maintaining healthy muscles as a way to improve quality of life as we age or face conditions like obesity and diabetes.