Grant recipient

Jesper B. Andersen

Viral exposures dictate the inflammatory microenvironment in liver cancers
Grant amount: DKK 9,999,492

Jesper B. Andersen says: “In Europe, the bile duct cancer incidence has increased 236% since 1980, with regional difference rising 7-fold over the past decade. Whereas cancer mortality has declined and therapy in other cancers improved, surgical resection still remains the only curative option for this patient group. The disease is often sporadic with unknown etiology, and patients are diagnosed at late-stage with locally advanced or metastatic disease, and a 5-year prognosis below 10%. In my research program, I will determine the viral exposures in a patient’s life and use these unique molecular footprints as guides to define the trigger of chronic inflammation and cancer. B cells are our humoral guardians responding to infections by producing antibodies. Yet, their pathobiological role and molecular states in contact with tumor cells are unknown. Thus, determining novel B cell tumor evasion mechanisms in bile duct cancer will allow us to start to develop specific B cell targets.”

Jesper B. Andersen is Danish, but has had his early career in the US, where he did his PhD and postdoc. In 2014 he was recruited as an associate professor to University of Copenhagen, and he was tenured in 2020.

Jesper B. Andersen
Jesper B. Andersen
Associate Professor, Biotech Research and Innovation Centre (BRIC), University of Copenhagen