Type 2 diabetes (T2D) is caused by genetic factors in combination with an unhealthy lifestyle, often with obesity. Gastric bypass surgery (GBP) leads to weight loss and can prevent or cure T2D, partly due to changes in the brain's regulation of the body's sugar levels. Conversely, the brain can contribute to the development of T2D itself, by alterations in its reactions to stress and reward and in nerve networks that monitor and regulate sugar levels.

We examine people with emerging or established T2D as well as healthy people. Disturbances in the brain's ability to regulate the body's sugar and energy balance via hormone and nerve signals are investigated using imaging techniques. To identify the type of brain cells that are important, some studies will be performed in rats that are prone to diabetes.

We aim to detect risk of diabetes earlier and to tailor individual prevention and therapy. We will propose and test novel medications, diets and lifestyle changes. This will also be supported by using large health care registers in Scandinavia.