Grant recipient

Henrik Dimke

Calcium-Sensing Receptor Signaling: Molecular Mechanisms of Pathogenesis in Kidney Stone Disease
Grant amount: DKK 9,985,395

There is a 10% risk of developing a kidney stone throughout ones lifetime and recurrence rate is high. The high risk of kidney stone disease imposes a significant burden on the healthcare system and emphasizes the need for improved therapy, including a wider range of medications to combat kidney stone formation. High calcium levels in urine lead to kidney stone formation and this risk can be reduced by decreasing calcium excretion into urine. The calcium-sensing receptor (CASR) is critical for regulating calcium transport in the kidney and the formation of kidney stones. I have discovered new evidence on how the CASR in the kidney increases calcium excretion via novel mechanisms. I will therefore investigate the underlying mechanisms of how the CASR regulates calcium transport in the kidney to uncover new pharmacological targets in the treatment of kidney stones.

Henrik Dimke
Professor, University of Southern Denmark
Department of Molecular Medicine, Cardiovascular and Renal Research Unit