Eva Hoffmann says: “Up to one in 20 children are born with congenital disorders that originated in the parents’ sperm or egg. This is much higher than in other organisms and we have long wanted to understand what happens when parents pass on their DNA to their children. Questions such as what makes us different from our parents, how does our DNA change, and what can go wrong. We are now in a position to start addressing these fundamental questions about human genetics. We will generate an atlas of sequences from human eggs, sperm and embryos from earliest stages of development to explore what genetic changes we see and how these processes occur. Some of the processes lead to severe genetic aberrations that result in infertility and pregnancy loss, whereas others sustain development – understanding these features of human genetic variation may provide insight into congenital disorders and their origins.”
Eva Hoffmann is Danish and was in 2015 recruited from UK to University of Copenhagen as Professor at ICMM.