Grant recipient

David E. Gloriam

GPCR Biased Signalling: Illuminating the Pathways to Function and Disease

David E. Gloriam says: “The project aims to find out how just one cell-surface receptor can elicit vastly different biological, therapeutic or adverse effects when activated by natural, medicinal or abused substances. My group will develop a new database resource to consolidate this new research field and conduct molecular modelling to select receptor targets and identify molecular mechanisms and substances. My Department colleagues will integrate pharmacology, crystallography and chemistry, and unique methods will be brought in through leading international collaborations. This will help us to understand receptor responses and provide starting-points for developing safer therapeutics.”

David E. Gloriam
Associate Professor, Department of Drug Design and Pharmacology
University of Copenhagen