Grant recipient
Benjamin Jensen says: “Non-alcoholic fatty liver disease (NAFLD) is an immunometabolic disease escalating at alarming pace globally. Development of novel therapeutics is hampered by lack of relevant animal models phenocopying human disease traits. The immunometabolism field generally agrees that improved gut health, including a nourished gut microbiota, is key to alleviate NAFLD. While strong evidence supports this hypothesis, the molecular and cell specific dependency of interorgan crosstalk needs further study. There is thus a significant knowledge-gap in the molecular understanding of interorgan communications in the onset, prevention and treatment of NAFLD. With this proposal, I aim to develop novel preclinical models phenocopying human pathophysiology, and leverage these models to investigate the organismal changes to nutritional and immunological challenges, thereby bridging the knowledge gap and enhance our understanding of immunometabolic diseases in general and NAFLD in particular.”
Benjamin Jensen
Host-Microbe Mutualism in Diet-induced Liver Disease: When Friends Become Foes
Grant amount: DKK 9,999,636